The Sherard Building

Edmund Halley Road

Oxford

OX4 4DQ

©2025 T-Cypher Bio All rights reserved

T-Cypher Bio, T-Cypher and T-Cα 

are trademarks of T-Cypher Bio Ltd

The Sherard Building

Edmund Halley Road

Oxford

OX4 4DQ

©2025 T-Cypher Bio All rights reserved

T-Cypher Bio is a registered trademark of T-Cypher Bio Ltd 

T-Cypher and T-Cα are trademarks of T-Cypher Bio Ltd

The Sherard Building

Edmund Halley Road

Oxford

OX4 4DQ

©2025 T-CypherBio All rights reserved

T-Cypher Bio is a registered trademark of T-Cypher Bio Ltd 

T-Cypher and T-Cα are trademarks of T-Cypher Bio Ltd

Pipeline

Our pipeline is focused on half-life extended T cell engager drug opportunities across a broad range of solid tumors as well as autoimmune indications

Novel targets

Solid tumor

program

Annual addressable metastatic US patients

Target and engager

Discovery

Lead optimisation

IND enabling

Status

Solid tumor

program

Annual addressable metastatic US patients

Target and engager

Discovery

Lead optimisation

IND enabling

Status

BA211

Dual-indication*

> 10,000

HLA-A2+

TC11

αCD3 TCE

DC Selected

IND

2026

2H27

BA225

Multi-indication*

> 60,000

HLA-A2+

TC25

αCD3 TCE

DC Selection

IND

2H26

1H28

Multiple

> 60,000

Pan-HLA+

Undisclosed

DC Selection

IND

2027

2028

*High potential indications including MSS CRC, Gastric, Oesophageal (Sq./Ad), Lung (Sq/Ad), Melanoma, HNSCC, Bladder, Pancreatic

Autoimmune

program

Multiple Autoimmune Indications

Multiple HLA Options

Undisclosed

Discovery

Other targets

Solid tumor

program

Annual addressable metastatic US patients

Target and engager

Discovery

Lead optimisation

IND enabling

Status

Solid tumor

program

Annual addressable metastatic US patients

Target and engager

Discovery

Lead optimisation

IND enabling

Status

BA202

BA201

BA2401

20,000-40,000

PRAME A2

MAGE-A4/A8

PRAME A24

Lead Selection

Pipeline

Our pipeline is focused on half-life extended T cell engager drug opportunities across a broad range of solid tumors as well as autoimmune indications

Novel targets

Solid tumor

program

Annual addressable metastatic US patients

Target and engager

Discovery

Lead optimisation

IND enabling

Status

Solid tumor

program

Annual addressable metastatic US patients

Target and engager

Discovery

Lead optimisation

IND enabling

Status

BA211

Dual-indication*

> 10,000

HLA-A2+

TC11

αCD3 TCE

DC Selected

IND

2026

2H27

BA225

Multi-indication*

> 60,000

HLA-A2+

TC25

αCD3 TCE

DC Selection

IND

2H26

1H28

Multiple

> 60,000

Pan-HLA+

Undisclosed

DC Selection

IND

2027

2028

*High potential indications including MSS CRC, Gastric, Oesophageal (Sq./Ad), Lung (Sq/Ad), Melanoma, HNSCC, Bladder, Pancreatic

Autoimmune

program

Multiple Autoimmune Indications

Multiple HLA Options

Undisclosed

Discovery

Other targets

Solid tumor

program

Annual addressable metastatic US patients

Target and engager

Discovery

Lead optimisation

IND enabling

Status

Solid tumor

program

Annual addressable metastatic US patients

Target and engager

Discovery

Lead optimisation

IND enabling

Status

BA202

BA201

BA2401

20,000-40,000

PRAME A2

MAGE-A4/A8

PRAME A24

Lead Selection

Pipeline

Our pipeline is focused on half-life extended T cell engager drug opportunities across a broad range of solid tumors as well as autoimmune indications

Novel targets

Solid tumor

program

Annual addressable metastatic US patients

Target and engager

Discovery

Lead optimisation

IND enabling

Status

Solid tumor

program

Annual addressable metastatic US patients

Target and engager

Discovery

Lead optimisation

IND enabling

Status

BA211

Dual-indication*

> 10,000

HLA-A2+

TC11

αCD3 TCE

DC Selected

IND

2026

2H27

BA225

Multi-indication*

> 60,000

HLA-A2+

TC25

αCD3 TCE

DC Selection

IND

2H26

1H28

Multiple

> 60,000

Pan-HLA+

Undisclosed

DC Selection

IND

2027

2028

*High potential indications including MSS CRC, Gastric, Oesophageal (Sq./Ad), Lung (Sq/Ad), Melanoma, HNSCC, Bladder, Pancreatic

Autoimmune

program

Multiple Autoimmune Indications

Multiple HLA Options

Undisclosed

Discovery

Other targets

Solid tumor

program

Annual addressable metastatic US patients

Target and engager

Discovery

Lead optimisation

IND enabling

Status

Solid tumor

program

Annual addressable metastatic US patients

Target and engager

Discovery

Lead optimisation

IND enabling

Status

BA202

BA201

BA2401

20,000-40,000

PRAME A2

MAGE-A4/A8

PRAME A24

Lead Selection

Novel targets

BA211

Dual-indication*

DC Selection

DC Selected

IND

2026

DC 2026

2027

IND 2H27

2H27

> 10,000

HLA-A2+ US patients

> 10,000

HLA-A2+

> 10,000

HLA-A2+

TC11

αCD3 TCE

Annual addressable metastatic patients

Annual addressable metastatic US patients

Annual addressable metastatic US patients

Target and engager

Solid tumor program

Pipeline

Pipeline

Our pipeline is focused on half-life extended T cell engager drug opportunities across a broad range of solid tumours as well as autoimmune indications

Our pipeline is focused on half-life extended T cell engager drug opportunities across a broad range of solid tumors as well as autoimmune indications

Other targets

Other targets

BA201

BA202

BA2401

BA202

BA201

BA2401

Discovery

Lead Selection

20-40k US patients

20,000-40,000

MAGE-A4/A8 HLA-A2

PRAME HLA-A2

PRAME HLA-A24

PRAME A2

MAGE-A4/A8

PRAME A24

Annual addressable metastatic patients

Annual addressable metastatic US patients

Annual addressable metastatic US patients

Target and engager

Solid tumor program

BA225

Multi-indication*

DC Selection

IND

2026

DC 2H26

2H26

2027

IND 1H28

1H28

> 60,000

HLA-A2+ US patients

> 60,000

HLA-A2+

> 60,000

HLA-A2+

TC25

Undisclosed

TC25

αCD3 TCE

Annual addressable metastatic patients

Annual addressable metastatic US patients

Annual addressable metastatic US patients

Target and engager

Target and engager

Solid tumor program

BA301

Multi-indication

Multiple

Autoimmune

Indications

Multiple Autoimmune Indications

Lead selection

Discovery

Autoimmune

Not HLA-restricted

Multiple HLA

Options

Multiple HLA Options

TC301

Undisclosed

Undisclosed

Annual addressable metastatic patients


Annual addressable metastatic US patients

Target and engager

Target and engager

Autoimmune program

Multiple

DC Selection

IND

2026

2027

2027

2028

DC 2026

DC 2027

IND 2027

IND 2028

> 60,000

HLA-A2+ US patients

> 60,000

HLA-A2+

> 60,000

HLA-A2+


Undisclosed

Annual addressable metastatic patients

Annual addressable metastatic US patients

Annual addressable metastatic US patients

Target and engager

Target and engager

Solid tumor program

*High potential indications for TCEs including MSS CRC, Gastric, Oesophageal (Sq./Ad), Lung (Sq/Ad), Melanoma, HNSCC, Bladder, Pancreatic

*High potential indications including MSS CRC, Gastric, Oesophageal (Sq./Ad), Lung (Sq/Ad), Melanoma, HNSCC, Bladder, Pancreatic

*High potential indications including MSS CRC, Gastric, Oesophageal (Sq./Ad), Lung (Sq/Ad), Melanoma, HNSCC, Bladder, Pancreatic

Novel targets

Novel targets