T-Cypher Bio is a seed-stage, innovative biotechnology company aiming to unlock an expansive target space to build a pipeline of novel, T-cell receptor (TCR)-based therapeutics. We are seeking a highly motivated Senior Scientist with cell biology expertise to help build our Cell Biology team.
What you will do
Play a key role in building our target and TCR discovery engine and our cell biology team as well as establishing our early pipeline. Working with others in Research you will assess target presentation by our novel peptide-HLA display platform and optimise target-T cell engagement assays. As well as developing the discovery platform you will apply it to identify novel target and TCR pairs, establishing our early pipeline of therapeutic candidates.
Key Responsibilities
- Design and conduct experiments in support of research objectives
- Develop and implement in-vitro immunological assays to interrogate T cell specificities and functional status
- Management and training of scientists
- Influence group and project meetings, offering leadership, insights and expertise to advance research projects
- Prioritisation of workloads and coordination of scientific work streams and processes
- Analyse and record experimental result and communicate findings to the team and to management
- Maintain and implement good laboratory practices, including accurate laboratory notebook systems, instrument and reagent maintenance, and personnel safety precautions
To be successful you will need
- PhD in Cellular Biology, Immunology, Cancer Biology, or a related discipline (or equivalent training and experience) and three years’ experience in biotech/pharma industry (or equivalent)
- In depth experience of cell culture
- Experience of PBMC isolation and primary immune cell culture primary T cell culture experience desirable)
- Experience of multi-parameter flow cytometry including panel development and troubleshooting
- Experience of cell sorting desirable
- Experience in developing and using multiple immune cell assays
- Desire to own and lead research projects whilst functioning as part of a wider research team
- Ability to adapt to multiple roles in a matrixed, fast-paced and evolving company
- Enjoy working towards challenging goals in a fast-moving environment
- Ability to follow and write protocols and SOPs
- Knowledge of health and safety regulations in a laboratory environment
- Strong organizational and communication skills (both written and verbal)
What we offer
- Competitive salary and benefits
- Modern, well equipped shared office and laboratory facilities on Oxford Science Park
- Training and development opportunities in-line with the company’s goals and growth plans
- An exciting opportunity to help establish an early-stage biotech with ambitions to impact patient’s lives